|
KMID : 0043320070300040397
|
|
Archives of Pharmacal Research
2007 Volume.30 No. 4 p.397 ~ p.401
|
|
|
Quinolone Alkaloids from Evodiae Fructus and Their Inhibitory Effects on Monoamine Oxidase
|
|
Han Xiang Hua
Hong Seong-Soo
Lee Dong-Ho
Lee Jung-Joon
Lee Moon-Soon
Moon Dong-Cheul
Han Kun
Oh Ki-Wan
Lee Myung-Koo
Ro Jai-Seup
Hwang Bang-Yeon
|
|
|
Abstract
|
|
|
|
1-Methyl-2-undecyl-4(1H)-quinolone (1) was previously isolated as a selective MAO-B inhibitor from the Evodiae Fructus. Further bioassay-guided purification led to the identification of five known quinolone alkaloids, 1-methyl-2-nonyl-4(1H)-quinolone (2), 1-methyl-2-[(Z)-6-undecenyl]- 4(1H)-quinolone (3), evocarpine (4), 1-methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)- quinolone (5), and dihydroevocarpine (6). All the isolates showed more potent inhibitory effects against MAO-B compared to MAO-A. The most MAO-B selective compound 5 among the isolates inhibited MAO-B in a competitive manner, according to kinetic analyses by Lineweaver- Burk reciprocal plots.
|
|
|
KEYWORD
|
|
|
Evodiae Fructus, Evodia rutaecarpa, Rutaceae, Monoamine oxidase inhibitor, Quinolone alkaloid
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|